The function of a protein is related to its three-dimensional structure and its three-dimensional structure to its primary sequence. Hence, both sequences and 3D structures of proteins can open to functional pieces of information. Analyses of protein sequences can provide pertinent pieces of information on protein stability and antigenicity and can detect residues involved in interaction sites. Studies of protein three-dimensional structures open to further possibilities and more precise predictions. Mutations of residues of the molecule, of its regulation sites and its antigenicity profile can be proposed in both cases.
