Biological membranes are made of lipids and proteins. They limit the cell entity and act as selectivity barriers for exchanges with the extra-cellular environment.
Biosiris_RA has developed algorithms to simulate membranes and their interactions with molecules (lipids, drugs, proteins).
Using these algorithms, interactions of drugs with membranes can be analyzed: their mode of insertion, their permeability, the lipid perturbation they trigger with eventually the detection of membrane fusion capacities.
For membrane proteins, experimental resolution of structures remains difficult and molecular modelling is a good alternative to these restrictions.
