The function of a protein is related to its three-dimensional structure and its three-dimensional structure to its primary sequence. Hence, both sequences and 3D structures of proteins can open to functional pieces of information. Analyses of protein sequences can provide pertinent pieces of information on protein stability and antigenicity and can detect residues involved in interaction sites. Studies of protein three-dimensional structures open to further possibilities and more precise predictions. Mutations of residues of the molecule, of its regulation sites and its antigenicity profile can be proposed in both cases.
Biological membranes are made of lipids and proteins. They limit the cell entity and act as selectivity barriers for exchanges with the extra-cellular environment.
Biosiris_RA has developed algorithms to simulate membranes and their interactions with molecules (lipids, drugs, proteins).
Using these algorithms, interactions of drugs with membranes can be analyzed: their mode of insertion, their permeability, the lipid perturbation they trigger with eventually the detection of membrane fusion capacities.
For membrane proteins, experimental resolution of structures remains difficult and molecular modelling is a good alternative to these restrictions.
Biosiris_RA organizes training sessions and seminars on different topics. Molecular Modeling is an efficient tool of biological approaches. It should, in a close future be part of any biological approaches: we can help you to understand its capacities and limits, to win over its major current possibilities and to understand how it may evoluate in the future.
