How to look at the results:

• This example's sequence : GWTLNSAGYLLGKINLKALAALAKKIL.
• __Prime structure

• __MFP_score.xls

Stability score of the Prime structure

• __RMS[9]_score.xls

Disorder score of the peptide.

RMS score up to 1.5 is a sign of structure order: all good structures have a very similar structure for the C-part.

RMS score higher than 1.5 is a sign of disorder: the secondary structure of the N-part is much more variable. This also goes with a lower stability as shown by the MFP scoring.

Addendum

• To view pdb files, you can download WINMGM on Biosiris web site or use other available software such as (SwissPDBviewer, Qmol, ...)

• Biosiris has also developed PepDesign, a consultancy platform for the design of peptides:

With special sequences: peptides including D and non-natural amino acids,
With special functions: high selectivity for a defined partner (Rational design of complementary peptides to the βAmyloid 29-42 fusion peptide: An application of PepDesign, Decaffmeyer M. et al BBA biomembranes),
With special functions: for example selectivity for membrane destabilization (“De novo” design of peptides with specific lipid-binding properties, Lins L. et al Biophys.J.).

If you have a specific problem, a question, please, contact us.

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